‘Magic bullet’ found in fight against leukaemia

 The progressive "magic ring" method makes use of particular antibody detection technology that could lessen the need for contemporary treatments that may be difficult, invasive and require prolonged health facility stays.

Acute myeloid leukemia (AML) typically affects older people with round 3 thousand humans identified every 365 days in the UK on my own. Current treatments might also additionally involve using a bone marrow transplant which can be painful, hard and can sometimes cause unsightly facet results.

The researchers decided that in AML there is a immoderate attention of a molecule referred to as Siglec-15 gift on the floor of the diseased cell. The institution recognized a molecule that would bind to Siglec-15, superimpose itself on the mobile and deliver with it a toxin that could potentially kill the diseased cell, removing the disease without harming healthy cells.

Published within the British Journal of Hematology and funded by means of the usage of the Biotechnology and Biological Sciences Research Council (BBSRC), the check grow to be led with the aid of the use of Dr Huan Cao, a researcher on the University of Aberdeen, together with colleagues from the University of Cambridge, in which numerous the artwork modified into completed REST OF ARTICLE.

This entry changed into published in Uncategorized on November 15, 2021.

Some RNA Molecules Have an Unexpected Sugar Coating

glycoRNA

A kind of molecules protrude from the cell floor, which incorporates lately determined glycoproteins, glycolipids, and glycoRNAs. This instance depicts the RNA as a double-stranded stem and loop, and the glycan as a Tinkertoy-like shape derived from it. Credit: Emily M.Eng/R. Flynn et al./Cell 2021

In a marvel discovery, scientists observed sugar-coated RNA molecules that decorated the floor of cells.

These so-known as "glycoRNAs" pop out of the outer membrane of mammalian cells, in which they may have interaction with different molecules. This discovery, posted May 17, 2021 within the magazine Cell, modifications the contemporary-day understanding of approaches the mobile manages RNAs and glycans.

"It changed into probable the biggest clinical marvel of my life," says have a look at writer Carolyn Bertozzi, an investigator at Stanford University's Howard Hughes Medical Institute. "According to the framework via which we recognize cell biology, there's no vicinity in which glycan sugars and RNA bodily contact every other." TO REST

This entry was published in Uncategorized on May 18, 2021.

The nanomachines of nature

Showing a bacterial flagellar motor in atomic element

An picture showing Cryo-EM

Cryo-electron microscopy exhibits a bacteriological flagellar motor in atomic-degree detail

In 1986, Eric Drexler published Engines of Making, a imaginative and prescient of what the burgeoning science of nanotechnology can also want to indicate for the destiny. Drexler claimed that nanoscale robots will sooner or later swim via our bloodstream, attacking invaders like viruses and disposing of sclerotic deposits from blood vessel walls.

Drexler laid out the mechanical factors of his imaginative and prescient in a 1992 ebook, Nanosystems, which argued that a "molecular assembler" would vicinity atoms exactly wherein we need them to assemble nanoscale devices like diamond-like carbon cars and gears. If such assemblers can be built, this fabrication process could be extended fee effectively to make us masters of recollect with atomic precision.

Books have had a great affect on the Futurists. In Ray Kurzweil's 2005 e-book The Singularity is Near, Drexlerian nanotechnology played a key function within the imagined merger of guy and system that Kurzweil believed ought to carry in a shape of immortality.