‘Magic bullet’ found in fight against leukaemia

 

The innovative "magic ring" method uses unique antibody detection technology that might lessen the want for cutting-edge remedies that may be hard, invasive and require lengthy health center stays.

Acute myeloid leukemia (AML) typically impacts older humans with round three thousand human beings diagnosed each 12 months inside the UK alone. Current treatments may additionally involve the use of a bone marrow transplant which may be painful, laborious and may every now and then purpose ugly side outcomes.

The researchers determined that in AML there's a excessive attention of a molecule referred to as Siglec-15 gift at the surface of the diseased cellular. The group identified a molecule that might bind to Siglec-15, superimpose itself on the mobile and carry with it a toxin that would potentially kill the diseased mobile, removing the disease without harming healthy cells.

Published inside the British Journal of Hematology and funded by using the Biotechnology and Biological Sciences Research Council (BBSRC), the take a look at become led by using Dr Huan Cao, a researcher at the University of Aberdeen, collectively with colleagues from the University of Cambridge, wherein a lot of the paintings changed into carried out REST OF ARTICLE

This entry changed into published in Uncategorized on November 15, 2021.

Some RNA Molecules Have an Unexpected Sugar Coating

glycoRNA

A type of molecules protrude from the cellular surface, which includes lately determined glycoproteins, glycolipids, and glycoRNAs. This example depicts the RNA as a double-stranded stem and loop, and the glycan as a Tinkertoy-like shape derived from it. Credit: Emily M.Eng/R. Flynn et al./Cell 2021

In a surprise discovery, scientists found sugar-coated RNA molecules that adorned the surface of cells.

These so-referred to as "glycoRNAs" come out of the outer membrane of mammalian cells, wherein they could interact with other molecules. This discovery, posted May 17, 2021 within the magazine Cell, modifications the modern-day understanding of ways the cellular manages RNAs and glycans.

"It turned into probably the biggest clinical surprise of my existence," says have a look at author Carolyn Bertozzi, an investigator at Stanford University's Howard Hughes Medical Institute. "According to the framework through which we understand mobile biology, there's no location wherein glycan sugars and RNA physically contact each other." TO REST

This entry was published in Uncategorized on May 18, 2021.

The nanomachines of nature

Showing a bacterial flagellar motor in atomic detail

An image displaying Cryo-EM

Cryo-electron microscopy reveals a bacteriological flagellar motor in atomic-level element

In 1986, Eric Drexler published Engines of Making, a vision of what the burgeoning science of nanotechnology may want to suggest for the future. Drexler claimed that nanoscale robots will sooner or later swim via our bloodstream, attacking invaders like viruses and putting off sclerotic deposits from blood vessel walls.

Drexler laid out the mechanical aspects of his imaginative and prescient in a 1992 e-book, Nanosystems, which argued that a "molecular assembler" would area atoms precisely where we want them to construct nanoscale gadgets like diamond-like carbon vehicles and gears. If such assemblers can be constructed, this fabrication process could be extended cost effectively to make us masters of remember with atomic precision.

Books have had a super influence at the Futurists. In Ray Kurzweil's 2005 ebook The Singularity is Near, Drexlerian nanotechnology played a key function inside the imagined merger of guy and gadget that Kurzweil believed could bring in a form of immortality.